王赓 研究员
个人简介：
王赓，博士，研究员。2018年于清华大学精仪系获博士学位，2018至2023年分别在华盛顿大学生物工程系和伊利诺伊大学厄巴纳-香槟分校贝克曼研究所从事博士后研究，2023至2026年在美国西北大学生物医学工程系担任副研究员(ResearchAssociate)。
研究聚焦跨尺度光学显微成像，发展纳米尺度染色质光学显微成像(VadimBackman实验室)和微米至毫米尺度无标记多模态非线性光学显微成像(Stephen Boppart实验室)新方法和新仪器。在Light: Science & Applications、Advanced Science、 Laser & Photonics Reviews、ACS Photonics、Advanced Photonics Nexus等期刊发表论文20余篇，入选封面论文3篇。撰写英文专著《The Supercontinuum Laser Source》(第4版)一章。申请美国发明专利3项，授权中国发明专利6项（转化1项）。共同主持美国国家科学基金，研制的无标记多模态非线性光学显微成像仪器转化到全球前三大药企葛兰素史克GSK用于生物制药研发。现担任IEEE Photonics Conference(IPC)委员会委员，2026 IPC“跨尺度光学显微成像”专题研讨会Chair，及JoVE“单分子定位成像专题”客座编辑，曾担任SPIE西部光子会议分会场主席。受邀在SPIE西部光子会议、加州大学洛杉矶分校电子系和普渡大学生物医学工程系作邀请报告。
邮箱：gengw@hust.edu.cn
研究方向：
无标记多模态非线性光学显微成像方法与仪器，染色质光谱纳米成像方法与仪器，及其计算方法与临床、生物应用，如癌症标志物、术中肿瘤边界、物理基因组学等。
科研项目：
[1]美国National Science Foundation,3D DNA Spectroscopic Photon-Localization Intrinsic-Contrast Nanoscopy, 475万元, 主持
[2]美国National Institutes of Health, U54CA268084, Northwestern University Center for Chromatin NanoImaging in Cancer (NU-CCNIC), 2023至2026, 参与
[3]美国National Institutes of Health, R01, R01CA241618, Imaging tumor microenvironment by OpticalFiber-Tethered Simultaneous Lifetime-resolved Autofluorescence-Multiharmonic (OFT-SLAM)microscopy, 2020至2023, 参与
[4]美国National Institutes of Health, R01, R01CA213149, Intraoperative Polarization-Sensitive OCT for Assessing Breast Tumor Margins, 2020至 2022,参与
论文专著与专利：
[1] Wang G, Li L, Sorrells JE, Chen J, Tu H. Gentle Label‐Free Nonlinear Optical Imaging Relaxes Linear‐Absorption‐Mediated Triplet. Advanced Science. 2025 Aug;12(32):e15648.(封面)
[2] Acosta N, Gong R, Su Y, Frederick J, Medina KI, Li WS, Mohammadian K, Almassalha L, Wang G*, Backman V*. Three-color single-molecule localization microscopy in chromatin. Light: Science & Applications. 2025 Mar 17;14(1):123.
[3] Wang G, Iyer RR, Sorrells JE, Aksamitiene E, Chaney EJ, Renteria CA, Park J, Shi J, Sun Y, Boppart SA, Tu H. Pixelation with Concentration‐Encoded Effective Photons for Quantitative Molecular Optical Sectioning Microscopy. Laser & photonics reviews. 2024 Oct;18(10):2400031.(封面)
[4] Su Y, Almassalha LM, Acosta N, Dunton CL, Medina KI, Liwag EP, Wang G*, Backman V*. Multiplexed chromatin analysis using optical spectroscopic statistical nanosensing. ACS photonics. 2025 Jul 10:10-21.
[5] Wang G, Shi J, Iyer RR, Sorrells JE, Tu H. Stable high-peak-power fiber supercontinuum generation for adaptive femtosecond biophotonics. Advanced Photonics Nexus. 2024 Jul 1;3(4):046012-.
[6] Wang G, Li L, Liao X, Wang S, Mitchell J, Rabel RC, Luo S, Shi J, Sorrells JE, Iyer RR, Aksamitiene E, Renteria CA, Chaney EJ, Milner DJ, Wheeler MB, Gillette MU, Schwing A, Chen J, Tu H. Supercontinuum intrinsic fluorescence imaging heralds ‘free view’of living systems. bioRxiv. 2024 Jan 26:2024-01.
[7] Wang G, Boppart SA, Tu H. Compact simultaneous label-free autofluorescence multi-harmonic microscopy for user-friendly photodamage-monitored imaging. Journal of biomedical optics. 2024 Mar 1;29(3):036501-.(封面)
[8] Gong R, Almassalha L, Zhang HF, Wang G*, Backman V*. Spectroscopic Super-resolution Imaging of DNA Molecules using Intrinsic Contrast. JoVE (Journal of Visualized Experiments). 2026 Mar 6(229):e69917.
[9] Acosta N, Gong R, Su Y, Frederick J, Medina K, Mohammadian K, Almassalha L, Wang G*, Backman V*. A Multilabel Single Molecule Localization Microscopy Protocol for Investigation of Chromatin in the Dense Nuclear Environment. Journal of Visualized Experiments (JoVE). 2026 Jun 5(232):e69868.
[10] Le NM†, Wang G†, Xie Z, Yue CF, Bamashmous S, Subhash H, Kilpatrick-Liverman L, Daubert DM. Quantitative analysis of gingival vascular morphology using optical coherence tomography angiography in induced gingivitis. Biomedical Optics Express. 2025 Oct 6;16(11):4300-11.
[11] Wang G, Le NM, Hu X, Cheng Y, Jacques SL, Subhash H, Wang RK. Semi-automated registration and segmentation for gingival tissue volume measurement on 3D OCT images. Biomedical Optics Express. 2020 Jul 22;11(8):4536-47.
[12] Wang G, Xing F, Wei M, You Z. Rapid optimization method of the strong stray light elimination for extremely weak light signal detection. Optics Express. 2017 Oct 12;25(21):26175-85.
[13] Wang G, Xing F, Wei M, Sun T, You Z. Optimization method of star tracker orientation for sun-synchronous orbit based on space light distribution. Applied Optics. 2017 May 18;56(15):4480-90.
[14] Wang G, Xing F, Wei M, Sun T, You Z. Optimization method for star tracker orientation in the sun-pointing mode. Chinese Optics Letters. 2017 Aug 10;15(8):081201.
[15] Wang G, Xing F, Wei M, You Z. Precision enhancement method for multiplexing image detector-based sun sensor with varying and coded apertures. Applied Optics. 2015 Dec 9;54(35):10467-72.
[16] Wei M, Xing F, You Z, Wang G. Multiplexing image detector method for digital sun sensors with arc-second class accuracy and large FOV. Optics Express. 2014 Sep 15;22(19):23094-107.
[17] Wang G, Boppart SA, and Tu H, "Supercontinuum Generation in Birefringent All Normal Dispersion Fibers," inThe Supercontinuum Laser Source(4thedition), pp. 595-607, 2023. Cham: Springer Publishing.
[18] Tu H, Wang G, Sorrells JE, Iyer RR, Shi J, inventors; University of Illinois System, assignee. Supercontinuum intrinsic fluorescence imaging. United States patent application US 19/036,969. 2025 Aug 28.
[19] Tu H, Wang G, inventors; University of Illinois System, assignee. Pixelating with concentration-encoded photoelectrons for molecular imaging. United States patent application US 19/036,550. 2025 Nov 6.
[20] Tu H, Wang G, inventors; University of Illinois System, assignee. Systems and Methods for Multiphoton Microscopy. United States patent application US 18/951,170. 2025 May 22.
荣誉获奖：
[1] 美国国家科学基金AGEP研究交流奖，2019
[2] 中国仪器仪表学会科学技术一等奖(4/7)，2018
