赵精晶 研究员
个人简介：
赵精晶，研究员、博导，国家级青年人才，湖北省高层次人才，华中卓越学者特聘教授，医疗装备科学与工程研究院研究员、学术评议委员会副主任，生命科学与技术学院、机械科学与工程学院双聘研究员。2024年在医疗装备科学与工程研究院组建“医学微系统实验室”。2018至2023年，斯坦福大学医学院结构生物学系Adam de laZerda实验室博士后和研究科学家、获美知名大学工学院和医学院Tenure Track教职，2017年获清华大学精仪系博士学位（清华大学优秀博士论文一等奖），2012年获北京理工大学机电学院学士学位。
研究聚焦于“以微纳系统创新为基础的生命科学原创仪器”，具体专注于衍射光学显微成像和光谱影像流式细胞仪。研究以临床重大需求导向，通过底层微纳技术创新，探索检测新原理、新方法，进而构建原创医学诊断仪器。近年来，以主要作者身份在NaturePhotonics、Optica、ACS Nano、Device、Nature Communications、ScienceAdvances、PhotoniX、Microsystems &Nanoengineering、Cytometry Part A等期刊发表论文30篇，申请中美发明专利19项。与清华大学、斯坦福大学、加州理工大学、剑桥大学、约翰霍普金斯大学、苏黎世大学、加州大学圣迭戈分校等国内外一流大学的知名实验室开展了在流式细胞术和衍射结构光显微成像方面的实质合作。研究受到国内外同行的认可，在International Society for Advancement of Cytometry（ISAC）的CYTO年会、SPIE Photonics West等国际会议等做邀请报告或担任分会场主席近20次，获ISAC国际发明家奖（International Innovator），2022年起出任CYTO年会组委会委员，2024年出任ISAC创新委员会的首任亚洲人主席（Chair of Innovation Committee at ISAC）、以及《Cytometry Part A》的Associate Editor，并当选中国生物工程学会细胞分析专业委员会常务委员、中国微米纳米技术学会微纳光器件与系统专业委员会理事、中国光学学会生物医学光子学专业委员会青年委员。
邮箱：jingjingzhao@hust.edu.cn
研究方向：
全光谱影像流式细胞仪：仪器创新、微流控分选、AI分析与临床应用
细胞振动谱光学相干显微：用于术中肿瘤边界快速病理诊断
微纳衍射光学理论与器件：结构光显微、超分辨针形/三维异形光束
家庭健康监测：尿液PCR和生化检测智能马桶
科研项目：
[1]湖北省技术创新计划项目,全血样本影像流式细胞分析和微流控分选仪研发, 2024至2027
[2]智能制造设备与技术全国重点实验室基本科研经费,全玻璃微流体芯片加工工艺, 2024至2024
[3]斯坦福大学Stanford University, Bio-X Interdisciplinary Initiative Seed Grant, IIP6-43, Non-invasive Virtual Biopsy for Basal Cell Cancer Diagnosis Using Machine Learning, 2022至2024
[4]美国Discovery Innovation Fund,医学脑影像技术研究, N/A, 3D brain tumor mapping with single-cell resolution as a neurosurgical tool, 2022至2024
[5]美国National Institutes of Health, NIH Director's Early Independence Award, DP5 OD031858, OCT as a Platform for Non-Invasive Virtual H&E Biopsy, 2021至2024
[6]美国Claire Giannini Foundation,临床医学影像技术研究, Bringing SM-OCT to the operating room , 2019至2022
[7]陈·扎克伯格生物中心Chan Zuckerberg Biohub,通用医学影像技术研究, Imaging of cell to-cell signaling at a cellular level in living subjects , 2017至2022
[8]美国National Cancer Institute,皮肤癌临床研究, K23CA211793, Repurposing systemic therapies to improve clinical outcomes in advanced basal cell cancer, 2018至2022
[9]基金委重大项目,多色拉曼光谱微流控芯片高通量稀有细胞分选系统, 2018至2022
[10]科技部重大科学仪器专项,高通量细胞分选多模式检测分析仪器及应用研究, 2012至2017
论文专著与专利：
[1]J. Zhao, K. Liang, A. Van Vleck, L. Du, Y. Winetraub, Y. Peng, and A. de la Zerda. "Extending Depth-of-Field of Arbitrary Diffractive Optics with Needle-Shaped Beam Modulation." ACS Photonics (2024).
[2]X. Guo, J. Zhao (共一), L. Sun, V. Gupta, L. Du, K. Sharma, A. Van Vleck et al. "Visualizing cortical blood perfusion after photothrombotic stroke in vivo by needle-shaped beam optical coherence tomography angiography." PhotoniX 5, no. 1 (2024): 1-17.
[3]R. Cao, Y. Luo, J. Zhao, Y. Zeng, Y. Zhang, Q. Zhou, A. de le Zerda, L. Wang.“Optical-resolution parallel ultraviolet photoacoustic microscopy for slide-free histology,” Science Advances, 10.50 (2024): eado0518.
[4]Y. Winetraub (共一), A. Van Vleck (共一), E. Yuan (共一), I. Terem (共一), J. Zhao, C. Yu, Y. Chan, H. Do, S. Shevidi, M. Mao, J. Yu, M. Hong, E. Blankenberg, K. Rieger, S. Chu, S. Asai, K. Sarin, A. de la Zerda. “Noninvasive Biopsy Using Micro-Registered Optical Coherence Tomography,” Science Advances 10, no. 15 (2024): eadi5794.
[5]W. He, J. Zhu, Y. Feng, K. You, H. Chai, Z. Sui, H. Hao, G. Qi, J. Zhao, L. Deng, R. Zhao, W. Wang,“Neuromorphic-Enabled Video-Activated Cell Sorting,” Nature Communications, 15.1 (2024): 10792.
[6]Y. Han, J. Zhao (共一/共通), Z. Chao, K. Liang, C. Zhang, L. Jiang, Z, Jiao, F, Bai, A. Tarnok, Z. You. “Imaging flow cytometry using linear array spot excitation,” Device (2023). (Cover story)
[7]X. Guo, X. Li, X. Wang, M. Li, X. Dai, L. Kong, Q. Hao, J. Zhao (共通), Y. Huang, L. Sun. “Wearable optical coherence tomography angiography probe for freely moving mice,” Biomedical Optics Express (2023).
[8]J. Zhao, A. Van Vleck, L. Du, S. Z. Aasi, K. Y. Sarin, A. de la Zerda.“Rapid Cellular-Resolution Skin Imaging with Optical Coherence Tomography using All-Glass Multifocal Metasurfaces,” ACS Nano (2023).
[9]Z. Chao, Y. Han, Z. Jiao, Z. You, and J. Zhao (通讯、邀稿). "Prism Design for Spectral Flow Cytometry." Micromachines 14, no. 2 (2023): 315.
[10]J. Zhao, Y. Winetraub, L. Du, A. Van Vleck, K. Ichimura, C. Huang, S. Z. Aasi, K. Y. Sarin, A. de la Zerda, “Flexible method for generating needle-shaped beam and its application in optical coherence tomography,” Optica (2022). DOI: 10.1364/OPTICA.386574.
[11]R. Cao, J. Zhao (共一), L. Li, L. Du, Y. Zhang, Y. Luo, L. Jiang, S. Davis, Q. Zou, A. de la Zerda, L. Wang, “Optical-resolution photoacoustic microscopy with a needle-shaped beam,” Nature Photonics (2022), 1-7.
[12]Z. Jiao, H. Yong, J. Zhao (通讯), Z. Chao, A. Tárnok, and Z. You. "Rapid switching and durable on-chip spark-cavitation-bubble cell sorter." Nature Microsystems & Nanoengineering 8, no. 1 (2022): 1-10.
[13]H. Yong, Z. Jiao, J. Zhao (通讯), Z. Chao, and Z. You. "A simple approach to fabricate multi-layer glass microfluidic chips based on laser processing and thermocompression bonding." Microfluidics and Nanofluidics 25, no. 9 (2021): 1-11.
[14]Z. Jiao, J. Zhao (通讯), Y. Han, Z. Chao, and Z. You. "Dynamics of spark cavitation bubbles in a microchamber." Microfluidics and Nanofluidics 25, no. 2 (2021): 1-8.
[15]H. Yong, J. Zhao (共一/共通), Z. Jiao, Z. Chao, A. Tárnok, and Z. You. "Diffractive beam shaper for multiwavelength lasers for flow cytometry." Cytometry Part A 99, no. 2 (2021): 194-204.
[16]J. Zhao, Y. Winetraub, E. Yuan, W.H. Chan, S.Z. Aasi, K.Y. Sarin, O. Zohar, and A. de la Zerda. "Angular compounding for speckle reduction in optical coherence tomography using geometric image registration algorithm and digital focusing." Scientific reports 10, no. 1 (2020): 1-11.
[17]Z. Jiao, J. Zhao, Z. Chao, Z. You, and J. Zhao. "An air-chamber-based microfluidic stabilizer for attenuating syringe-pump-induced fluctuations." Microfluidics and Nanofluidics 23, no. 2 (2019): 1-10.
[18]J. Zhao, and Z. You. "Spark‐generated microbubble cell sorter for microfluidic flow cytometry." Cytometry Part A 93, no. 2 (2018): 222-231. (Cover story)
[19]J. Zhao, and Z. You. "Using binary optical elements (BOEs) to generate rectangular spots for illumination in micro flow cytometer." Biomicrofluidics 10, no. 5 (2016): 054111.
[20]J. Zhao, and Z. You. "A microflow cytometer with a rectangular quasi-flat-top laser spot." Sensors 16, no. 9 (2016): 1474.
[21]J. Zhao, and Z. You. "Combining microfluidic chip and binary optical element for flow cytometry." 2016 IEEE SENSORS, pp. 1-3. IEEE, 2016.
[22]Y. Han, Y. Cao, J. Zhao, Y. Yin, L. Ye, X. Wang, and Z. You. "A self-powered insole for human motion recognition." Sensors 16, no. 9 (2016): 1502.
[23]J. Zhao, and Z. You. "Microfluidic hydrodynamic focusing for high-throughput applications." Journal of Micromechanics and Microengineering 25, no. 12 (2015): 125006.
[24]J. Zhao, G. Shi, and L. Du. "Miniaturized air-driven planar magnetic generators." Energies 8, no. 10 (2015): 11755-11769.
[25]J. Zhao, and Z. You. "A shoe-embedded piezoelectric energy harvester for wearable sensors." Sensors 14, no. 7 (2014): 12497-12510.
[26]J. Zhao, and Z. You. "Models for 31-mode PVDF energy harvester for wearable applications." The Scientific World Journal 2014 (2014).
[27]Q. Zhou, J. Zhao (共一), C. Glück , Y. Liu, L. Du, L. Glandorf, Z. Chen, L. Jiang, B. Weber, A. de la Zerda, D. Razansky, “Needle beam two-photon microscopy for simultaneous multiplane neural and vascular imaging in awake mice,” Nature Communications (2ndreview).
[28]J. Zhao and A. de la Zerda.“Method and system for generation of a needle-shaped beam by a diffractive optical element for use in extended depth-of-focus optical coherence tomography.” US20230384609A1.
[29]Z. You, Z. Jiao, J. Zhao, Y. Han. “Sorting device and method based on electric spark cavitation bubbles.” China patent application. CN114292741A
[30]Z. You, Y. Han, J. Zhao. “Imaging flow cytometer by the laser spot array.” CN113624666A.
[31]Z. You, Z. Chao, J. Zhao. “The design method of the optical waveguide for the fluorescence detection of the flow cytometer.” CN114136867A.
[32]Z. You, Z. Chao, J. Zhao. “The design method of the dispersion system for the fluorescence detection of the flow cytometer, substantive examination.” CN114112873A.
[33]Z. You, Y. Han, J. Zhao. “An imaging flow cytometry system based on spectral labeling and light frequency swept.” CN202011619742.
[34]Z. You, J. Zhao. “Cell sorting device and method based on micro spark cavitation.” CN107297334A.
[35]Z. You, J. Zhao, B. Li. “Flow cytometry detection apparatus and method.” CN105717035A. WO2017173896A1.
[36]Z. You, J. Zhao, B. Li.“Microchannel structure utilizing single-path sheath fluid for implementing two-dimensional hydrodynamic focusing and microfluidic chip.” CN105854963A. WO2017173820A1.
[37]Z. You, J. Zhao. “Method for manufacturing multilayer microfluidic chip suitable for batch production”. CN106391151B. WO2018040277A1.
[38]Z. You, J. Zhao. “Method and system for automatic alignment of microfluidic chip based on binary optical device.” CN106383081B. WO2018035977A1.
[39]Z. You, J. Zhao. “Micro-channel structure used for two-dimensional hydrodynamic focusing and microfluid chip”. CN105149019A.
[40]Z. You, J. Zhao. “Insole-type piezoelectric generator”. CN103580535A.
[41]G. Shi, L. Sui, L. Du, and J. Zhao. “Magnetoelectric micro electric generator of axial magnetic field”. CN103280910A.
[42]J. Zhao, A. de la Zerda, Chapter “OCT Contrast Agents for Molecular Imaging, Angiography, and Other Functional Imaging”, Optical Coherence Tomography: Technology and Applications (2025版，排版中).
[43]J. Zhao, A. de la Zerda, A. Wax, E. T. Jelly, G. R. Untracht, S. Georgiou, P. Wijesinghe, K. Dholakia, P. E. Andersen, Chapter “OCT with Enhanced Depth Penetration”, Optical Coherence Tomography: Technology and Applications (2025版，排版中).
荣誉获奖：
[1]华中卓越学者特聘教授，华中科技大学，2024
[2]国家级青年人才项目，2023
[3]InternationalInnovator Award, International Society for Advancement of Cytometry, 2021.
[4]清华大学优秀博士论文一等奖，2017
[5]Outstanding Poster Award at CYTO Congress, International Society for Advancement of Cytometry, 2017
